Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B3FV
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| Former ID |
DCL000902
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| Drug Name |
NVP-LAQ824
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| Synonyms |
Dacinostat; 404951-53-7; LAQ824; LAQ-824; LAQ824 (Dacinostat); UNII-V10P524501; (E)-N-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide; CHEMBL356066; V10P524501; (2E)-N-hydroxy-3-[4-({(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide; Dacinostat [INN]; (E)-N-Hydroxy-3-[4-[[2-hydroxyethyl-[2-(1H-indol-3-yl)ethyl]amino]meth yl]phenyl]prop-2-enamide; (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl}phenyl)prop-2-enamide; Dacinostat; NVP-LAQ 824; NVP-LAQ824, Dacinostat, LAQ824; LBH539
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| Drug Type |
Small molecular drug
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| Indication | Mood disorder [ICD-11: 6A60-6E23; ICD-9: 296] | Phase 3 | [1] | |
| leukaemia [ICD-11: 2A60-2B33; ICD-10: C91-C95; ICD-9: 204-208] | Discontinued in Phase 1/2 | [1] | ||
| Multiple myeloma [ICD-11: 2A83; ICD-10: C90.0] | Investigative | [2] | ||
| Company |
Corcept Therapeutics
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H25N3O3
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)C=CC(=O)NO
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| InChI |
1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+
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| InChIKey |
BWDQBBCUWLSASG-MDZDMXLPSA-N
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| CAS Number |
CAS 404951-53-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
11969807, 14877864, 43037729, 46519450, 50075745, 53260712, 53788896, 56314024, 57369859, 87226484, 99375472, 99430921, 99436979, 103381801, 114573086, 124756994, 125163799, 126671546, 127342238, 127342239, 131313854, 131480755, 134339354, 134340172, 134964541, 135135691, 135357949, 136367294, 136920345, 137053873, 140114881, 144116128, 152039207, 152344356, 162037430, 162202709, 162202786, 164193981, 172821429, 175608164, 180371815, 186024308, 187051799, 188899511, 198961127, 210274900, 210280535, 223669689, 223704892, 223705151
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| ChEBI ID |
CHEBI:94063
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| SuperDrug ATC ID |
G03XB01
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| SuperDrug CAS ID |
cas=084371653
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92. | |||
| REF 2 | Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. | |||
| REF 3 | NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22. | |||
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