Drug Information
Drug General Information | Top | |||
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Drug ID |
D0B3QM
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Former ID |
DAP000471
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Drug Name |
Metyrosine
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Synonyms |
Demser; Methyltyrosine; Metirosina; Metirosine; Metirosinum; Racemetirosina; Racemetirosine; Racemetirosinum; Metyrosine[USAN]; Racemetirosine [INN]; M 8131; MK 781; Alpha-MPT; Alpha-Methyltyrosine; Demser (TN); H 9/88; L 588357-0; L-AMPT; M-5185; MK-781; Metirosina [INN-Spanish]; Metirosine (INN); Metirosinum [INN-Latin]; Metyrosine (USP); Racemetirosina [INN-Spanish]; Racemetirosinum [INN-Latin]; DL-alpha-Methyltyrosine; L-588357-0; Alpha-Methyl-L-tyrosine; Alpha-Methyl-dl-tyrosine; Alpha-Methyl-p-tyrosine; Alpha-Methyl-para-tyrosine; A-methyl-L-p-tyrosine; Alpha-Methyl-L-P-Tyrosine; Alpha-Methyltyrosine, (L)-Isomer; DL-alpha-Methyl-p-tyrosine; L-alpha-Methyl-p-tyrosine; Alpha-Methyltyrosine, (D,L)-Isomer; DL-2-Methyl-3-(4-hydroxyphenyl)alanine; Alpha-Methyltyrosine, (+,-)-Isomer; L-2-Methyl-3-(4-hydroxy-phenyl)alanine; (+-)-alpha-Methyl-DL-tyrosine; (-)-(S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure; (-)-alpha-Methyl-DL-tyrosine; (-)-alpha-Methyl-L-tyrosine; (2R)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; (R,S)-2-Amino-3-(4-hydroxyphenyl)-2-methylpropionsaeure; (S)-alpha-Methyltyrosine; 2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid; 4-Hydroxy-alpha-methylphenylalanine
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Drug Type |
Small molecular drug
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Indication | Pheochromocytoma [ICD-11: 5A75; ICD-10: E27.5] | Approved | [1], [2] | |
Therapeutic Class |
Anticancer Agents
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Structure |
Download2D MOL |
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Formula |
C10H13NO3
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Canonical SMILES |
CC(CC1=CC=C(C=C1)O)(C(=O)O)N
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InChI |
1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
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InChIKey |
NHTGHBARYWONDQ-JTQLQIEISA-N
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CAS Number |
CAS 672-87-7
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PubChem Compound ID | ||||
PubChem Substance ID |
10123, 7847827, 7979956, 10298807, 11372831, 11491661, 15171600, 15219928, 17405372, 24278155, 26613199, 29215162, 36885208, 46386969, 46506079, 47365474, 47885670, 48416274, 50106644, 50106645, 50106646, 53777917, 56311235, 57403650, 78199915, 90341393, 92304372, 103770845, 104625267, 117393519, 119503147, 121361507, 124750020, 124891670, 128704144, 131323203, 134337766, 135610156, 137008350, 137483445, 144204805, 160964108, 163564765, 164230370, 164806369, 170465112, 170505775, 172088459, 175268174, 178103538
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ChEBI ID |
CHEBI:6912
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ADReCS Drug ID | BADD_D01451 | |||
SuperDrug ATC ID |
C02KB01
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Target and Pathway | Top | |||
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Target(s) | Tyrosine 3-monooxygenase (TH) | Target Info | Binder | [3] |
BioCyc | Catecholamine biosynthesis | |||
KEGG Pathway | Tyrosine metabolism | |||
Metabolic pathways | ||||
Dopaminergic synapse | ||||
Prolactin signaling pathway | ||||
Parkinson's disease | ||||
Cocaine addiction | ||||
Amphetamine addiction | ||||
Alcoholism | ||||
Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
Parkinson disease | ||||
Dopamine receptor mediated signaling pathway | ||||
Nicotine pharmacodynamics pathway | ||||
Pathwhiz Pathway | Catecholamine Biosynthesis | |||
Pathway Interaction Database | ATF-2 transcription factor network | |||
AP-1 transcription factor network | ||||
p38 signaling mediated by MAPKAP kinases | ||||
Alpha-synuclein signaling | ||||
WikiPathways | Monoamine Transport | |||
SIDS Susceptibility Pathways | ||||
Biogenic Amine Synthesis | ||||
Dopaminergic Neurogenesis | ||||
Metabolism of amino acids and derivatives | ||||
Dopamine metabolism | ||||
Parkinsons Disease Pathway | ||||
Nicotine Activity on Dopaminergic Neurons |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6956). | |||
REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017871. | |||
REF 3 | Dopamine beta-hydroxylase deficiency. A genetic disorder of cardiovascular regulation. Hypertension. 1991 Jul;18(1):1-8. |
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