Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0B4GV
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| Former ID |
DNC007891
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| Drug Name |
4-amino-2H-chromen-2-one
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| Synonyms |
4-Amino-chromen-2-one; 4-Aminocoumarin; 53348-92-8; 4-amino-2H-chromen-2-one; 4-Amino-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one, 4-amino-; UNII-SCI2054E4F; CHEMBL240482; SCI2054E4F; Coumarin, 4-amino-; 4-aminochromen-2-one; AC1LGGAS; Coumarin, 4-amino- (7CI); SCHEMBL4396062; AC1Q69X0; CTK7H2649; DTXSID90201509; MolPort-000-000-981; AHZAKFLOHIRCDU-UHFFFAOYSA-N; ZINC337346; STL371135; BDBM50226833; 4-[Amino]-2H-1-benzopyran-2-one; AKOS004909244; FCH1162846; MCULE-3726196442; MB00371; LS-39436; DB-071668; KB-189290; FT-0740005; A58124
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C9H7NO2
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| Canonical SMILES |
C1=CC=C2C(=C1)C(=CC(=O)O2)N
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| InChI |
1S/C9H7NO2/c10-7-5-9(11)12-8-4-2-1-3-6(7)8/h1-5H,10H2
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| InChIKey |
AHZAKFLOHIRCDU-UHFFFAOYSA-N
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| CAS Number |
CAS 53348-92-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Quinone reductase 1 (NQO1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Ubiquinone and other terpenoid-quinone biosynthesis | |||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathwhiz Pathway | Vitamin K Metabolism | |||
| Pathway Interaction Database | Validated transcriptional targets of TAp63 isoforms | |||
| WikiPathways | Estrogen metabolism | |||
| Oxidative Stress | ||||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Metabolism of amino acids and derivatives | ||||
| Aryl Hydrocarbon Receptor | ||||
| Dopamine metabolism | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human panc... J Med Chem. 2007 Dec 13;50(25):6316-25. | |||
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