Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0C3ZR
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| Former ID |
DCL000246
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| Drug Name |
TG100-115
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| Synonyms |
TG-100115; TG-100-115; TG100115, TG100-115; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol; 3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol; 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol
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| Drug Type |
Small molecular drug
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| Indication | Angioedema [ICD-11: 4A00.15] | Phase 1/2 | [1], [2] | |
| Myocardial infarction [ICD-11: BA41-BA43] | Phase 1/2 | [1], [2] | ||
| Company |
TargeGen
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| Structure |
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Download2D MOL |
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| Formula |
C18H14N6O2
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| Canonical SMILES |
C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N
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| InChI |
1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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| InChIKey |
UJIAQDJKSXQLIT-UHFFFAOYSA-N
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| CAS Number |
CAS 677297-51-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
15447068, 22769253, 40555380, 56374226, 77520336, 87550994, 87692392, 93581263, 99437104, 103526391, 124757182, 125163986, 125568862, 126731485, 131480851, 134338906, 136340114, 136367398, 136367762, 139630620, 152258087, 152344030, 160646926, 162011833, 162037556, 162202597, 162628940, 172650249, 172919686, 174006467, 174561103, 177748756, 178102341, 180189211, 186014830, 188899570, 198958964, 202556337, 223400365, 223678544, 223705052, 223895079, 226693154, 242060047, 245512251, 251971175, 252216453, 252451592, 252543376
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| ChEBI ID |
CHEBI:94691
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5715). | |||
| REF 2 | Pharmacologic therapeutics for cardiac reperfusion injury. Expert Opin Emerg Drugs. 2007 Sep;12(3):367-88. | |||
| REF 3 | Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic can... J Pharmacol Exp Ther. 2009 Mar;328(3):758-65. | |||
| REF 4 | Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction. Biochem Soc Trans. 2007 Apr;35(Pt 2):204-6. | |||
| REF 5 | PI3Kgamma inhibition: towards an 'aspirin of the 21st century' Nat Rev Drug Discov. 2006 Nov;5(11):903-18. | |||
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