Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D4HN
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| Drug Name |
Podofilox
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| Synonyms |
podophyllotoxin; 518-28-5; Condylox; Condyline; Wartec; Podophyllotoxin 7; Podophyllinic acid lactone; Warticon; (-)-Podophyllotoxin; Podofilox [USAN]; CCRIS 565; UNII-L36H50F353; Podophyllotoxin, 95%; HSDB 7238; NSC24818; CHEMBL61; EINECS 208-250-4; NSC 24818; (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; MLS000069495; AI3-50456; CHEBI:50305; Podofilox (USAN); L36H50F353; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; Podophyllotoxin
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| Drug Type |
Small molecular drug
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| Indication | Condyloma [ICD-11: 1A95] | Approved | [1] | |
| External genital and perianal wart [ICD-11: 1A95; ICD-10: A63.0] | Approved | [1] | ||
| Verruca vulgaris [ICD-11: 1E80; ICD-10: B07] | Approved | [1] | ||
| Company |
Actavis Laboratories Ut Inc
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| Structure |
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Download2D MOL |
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| Formula |
C22H22O8
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
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| InChI |
1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
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| InChIKey |
YJGVMLPVUAXIQN-XVVDYKMHSA-N
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| CAS Number |
CAS 518-28-5
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:50305
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| ADReCS Drug ID | BADD_D01790 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II (TOP2) | Target Info | Modulator | [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39. | |||
| REF 3 | Identification of therapeutic candidates for chronic lymphocytic leukemia from a library of approved drugs.PLoS One.2013 Sep 20;8(9):e75252. | |||
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