Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0D4SK
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| Former ID |
DNC011511
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| Drug Name |
6,8-Dichloro-1,2,3,4-tetrahydro-acridin-9-ylamine
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| Synonyms |
CHEMBL48643; Tacrine deriv. 2; 6,8-dichloro-1,2,3,4-tetrahydroacridin-9-amine; SCHEMBL15168338; BDBM10516; ZINC13492737; AKOS011484747
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C13H12Cl2N2
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| Canonical SMILES |
C1CCC2=NC3=C(C(=CC(=C3)Cl)Cl)C(=C2C1)N
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| InChI |
1S/C13H12Cl2N2/c14-7-5-9(15)12-11(6-7)17-10-4-2-1-3-8(10)13(12)16/h5-6H,1-4H2,(H2,16,17)
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| InChIKey |
ISUJWDYWYFLQFP-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Acetylcholinesterase (AChE) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Glycerophospholipid metabolism | |||
| Cholinergic synapse | ||||
| Panther Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Pathwhiz Pathway | Phospholipid Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Acetylcholine Synthesis | ||||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1779-82. | |||
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