Drug Information
Drug General Information | Top | |||
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Drug ID |
D0D8DA
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Former ID |
DIB013048
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Drug Name |
KAG-308
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Synonyms |
EP4 agonists (ulcerative colitis), Kaken
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Indication | Ulcerative colitis [ICD-11: DD71; ICD-9: 556] | Investigative | [1] | |
Company |
Kaken Pharmaceutical Co Ltd
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Structure |
Download2D MOL |
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Formula |
C24H30F2N4O3
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Canonical SMILES |
CC1=CC(=CC=C1)C(C)C(C=CC2C(CC3C2C(C(=CCCCC4=NNN=N4)O3)(F)F)O)O
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InChI |
1S/C24H30F2N4O3/c1-14-6-5-7-16(12-14)15(2)18(31)11-10-17-19(32)13-20-23(17)24(25,26)21(33-20)8-3-4-9-22-27-29-30-28-22/h5-8,10-12,15,17-20,23,31-32H,3-4,9,13H2,1-2H3,(H,27,28,29,30)/b11-10+,21-8-/t15-,17+,18-,19-,20+,23-/m1/s1
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InChIKey |
KSELABKNBIUMGG-YGBAREPYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin E2 receptor EP4 (PTGER4) | Target Info | Agonist | [1] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
Renin secretion | ||||
Pathways in cancer | ||||
NetPath Pathway | FSH Signaling Pathway | |||
IL2 Signaling Pathway | ||||
IL4 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Prostanoid ligand receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Vitamin D Receptor Pathway | ||||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). |
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