Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0D8EY
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| Former ID |
DIB009149
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| Drug Name |
HLF 1-11
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| Synonyms |
Antimicrobial peptides, AM-Pharma; HLF(1-11); Antimicrobial peptides (bacterial infections), AM-Pharma; Antimicrobial peptides (fungal infections), AM-Pharma; HLF 1-11, AM-Pharma; Human lactoferrin 1-11, AM-Pharma; Human lactoferrin peptides (antibacterial), AM-Pharma
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| Drug Type |
Peptide
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| Indication | Bacteremia [ICD-11: 1A73; ICD-10: A54.4, A54.8] | Phase 1/2 | [1] | |
| Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Phase 1/2 | [2] | ||
| Candidemia [ICD-11: 1F23.3Y; ICD-10: B37; ICD-9: 112] | Phase 1/2 | [3] | ||
| Company |
Pharming Group NV
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Lactotransferrin (LTF) | Target Info | Modulator | [4] |
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Reactome | ROS production in response to bacteria | |||
| Amyloid formation | ||||
| WikiPathways | Latent infection of Homo sapiens with Mycobacterium tuberculosis | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis (LIST). U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT00509847) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Bacteremia Due to S. Epidermidis. U.S. National Institutes of Health. | |||
| REF 3 | ClinicalTrials.gov (NCT00509834) A Study on the Tolerability and Early Efficacy of hLF1-11 in Patients With Proven Candidaemia (SLIC). U.S. National Institutes of Health. | |||
| REF 4 | The synthetic N-terminal peptide of human lactoferrin, hLF(1-11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2004 Dec;48(12):4919-21. | |||
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