Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E1LB
|
|||
| Former ID |
DIB009401
|
|||
| Drug Name |
MK-2578
|
|||
| Indication | Anemia [ICD-11: 3A00-3A9Z; ICD-9: 280-285] | Phase 2 | [1] | |
| Company |
Merck Bioventures
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Erythropoietin (EPO) | Target Info | Agonist | [2] |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| HIF-1 signaling pathway | ||||
| PI3K-Akt signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Hematopoietic cell lineage | ||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | |||
| Signaling events mediated by Stem cell factor receptor (c-Kit) | ||||
| EPO signaling pathway | ||||
| HIF-1-alpha transcription factor network | ||||
| Reactome | Regulation of gene expression by Hypoxia-inducible Factor | |||
| WikiPathways | EPO Receptor Signaling | |||
| Hematopoietic Stem Cell Differentiation | ||||
| Differentiation Pathway | ||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00968617) A Study of MK2578 in Patients With Chronic Kidney Disease Who Are Not on Dialysis (2578-002). U.S. National Institutes of Health. | |||
| REF 2 | Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636. | |||
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