Drug Information
Drug General Information | Top | |||
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Drug ID |
D0E1SQ
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Former ID |
DIB007338
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Drug Name |
BIBW-22
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Synonyms |
RMKP-22; BIBW-22-BS
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Drug Type |
Small molecular drug
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Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Terminated | [1] | |
Company |
Boehringer Ingelheim Corp
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Structure |
Download2D MOL |
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Formula |
C30H43N7O4
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Canonical SMILES |
CC1CN(CC(O1)C)C2=NC3=C(C(=NC(=N3)N4CC(OC(C4)C)C)N(CCO)CC(C)(C)O)N=C2C5=CC=CC=C5
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InChI |
1S/C30H43N7O4/c1-19-14-36(15-20(2)40-19)27-24(23-10-8-7-9-11-23)31-25-26(32-27)33-29(37-16-21(3)41-22(4)17-37)34-28(25)35(12-13-38)18-30(5,6)39/h7-11,19-22,38-39H,12-18H2,1-6H3/t19-,20+,21-,22+
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InChIKey |
JNHIGDFEPXMPAO-COPRSSIGSA-N
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CAS Number |
CAS 137694-16-7
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Phosphodiesterase 1 (PDE1) | Target Info | Inhibitor | [2] |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004174) | |||
REF 2 | BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Mol Pharmacol. 1996 Sep;50(3):482-92. |
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