Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0E7LU
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| Former ID |
DIB018583
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| Drug Name |
3,5-DHPG
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| Synonyms |
3,5-dihydroxyphenylglycine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C8H9NO4
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| Canonical SMILES |
C1=C(C=C(C=C1O)O)C(C(=O)O)N
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| InChI |
1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13)
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| InChIKey |
HOOWCUZPEFNHDT-UHFFFAOYSA-N
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| CAS Number |
CAS 146255-66-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7724834, 10234545, 15120667, 26751684, 44436914, 50064450, 53788934, 57338377, 79707942, 85085469, 85208917, 91703835, 103811218, 103988486, 104380249, 117542958, 124879871, 128090722, 131304308, 132512948, 135066704, 135649729, 137088060, 162022565, 177748557, 179294194, 196362806, 225046176, 227716184, 241181626, 242084408, 249498318, 252160408
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| ChEBI ID |
CHEBI:93822
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 1 (mGluR1) | Target Info | Agonist | [2] |
| Metabotropic glutamate receptor 5 (mGluR5) | Target Info | Agonist | [3] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Long-term potentiation | ||||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Huntington's disease | ||||
| FoxO signaling pathway | ||||
| Long-term depression | ||||
| Estrogen signaling pathway | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group I pathway | ||||
| Endogenous cannabinoid signaling | ||||
| Reactome | G alpha (q) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1367). | |||
| REF 2 | [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93. | |||
| REF 3 | Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections. J Neurochem. 2000 Dec;75(6):2590-601. | |||
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