Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0G5PF
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| Former ID |
DNCL003108
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| Drug Name |
AFQ056
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| Synonyms |
Mavoglurant
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| Drug Type |
Small molecular drug
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| Indication | Fragile X syndrome [ICD-11: LD55; ICD-10: Q99.2] | Phase 2/3 | [1], [2] | |
| Company |
Novartis
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| Structure |
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Download2D MOL |
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| Formula |
C19H23NO3
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| Canonical SMILES |
CC1=CC(=CC=C1)C#CC2(CCCC3C2CCN3C(=O)OC)O
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| InChI |
1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1
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| InChIKey |
ZFPZEYHRWGMJCV-ZHALLVOQSA-N
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| CAS Number |
CAS 543906-09-8
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7586). | |||
| REF 2 | ClinicalTrials.gov (NCT01433354) Long-term, Safety and Tolerability Study of AFQ056 in Adolescent Patients With Fragile X Syndrome (Open-label). U.S. National Institutes of Health. | |||
| REF 3 | Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41. | |||
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