Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0G8BN
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| Former ID |
DNC004663
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| Drug Name |
CAPSAZEPINE
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| Synonyms |
capsazepine; 138977-28-3; capsazepin; N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide; UNII-LFW48MY844; N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide; CHEMBL391997; LFW48MY844; ST50826300; CHEBI:70773; N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide; N-(2-[4-chlorophenyl]ethyl)-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H21ClN2O2S
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| Canonical SMILES |
C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
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| InChI |
1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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| InChIKey |
DRCMAZOSEIMCHM-UHFFFAOYSA-N
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| CAS Number |
CAS 138977-28-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3153122, 4689287, 7978851, 8794630, 11110887, 11113514, 11120274, 11120762, 11121250, 11121615, 11122095, 11362684, 11365246, 11367808, 11370639, 11370640, 11373409, 11375970, 14755701, 17404936, 24277967, 26751729, 26758380, 30091315, 47515104, 47810533, 48258992, 49688358, 49877927, 50104422, 50104423, 52479418, 53777479, 53790523, 56463490, 57409553, 71822557, 85084530, 85230948, 85788750, 90340779, 91611492, 92303760, 92309966, 99300878, 99302398, 103546395, 103904082, 111358572, 113635233
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| ChEBI ID |
CHEBI:70773
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Inhibitor | [2] |
| Transient receptor potential cation channel V4 (TRPV4) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2461). | |||
| REF 2 | The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. J Med Chem. 2007 May 31;50(11):2589-96. | |||
| REF 3 | Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists. Bioorg Med Chem Lett. 2003 May 5;13(9):1549-52. | |||
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