Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0GT8W
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| Drug Name |
BMS-587101
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| Synonyms |
BMS-688521
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| Indication | Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Discontinued in Phase 2 | [1] | |
| Company |
Bristol Myers Squibb
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| Structure |
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Download2D MOL |
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| Formula |
C26H20Cl2N4O4S
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| Canonical SMILES |
CN1C(=O)N(C(=O)C12CN(CC2C3=CC=C(C=C3)C#N)CC4=CC(=CS4)C(=O)O)C5=CC(=CC(=C5)Cl)Cl
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| InChI |
1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m0/s1
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| InChIKey |
NXNKJLOEGWSJGI-BKMJKUGQSA-N
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| CAS Number |
CAS 509083-77-6
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| PubChem Compound ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50. | |||
| REF 2 | Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-(... J Med Chem. 2010 May 13;53(9):3814-30. | |||
| REF 3 | Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thioph... J Med Chem. 2006 Nov 30;49(24):6946-9. | |||
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