Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H0HR
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| Former ID |
DIB021069
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| Drug Name |
torin 1
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| Synonyms |
Torin-1
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C35H28F3N5O2
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| Canonical SMILES |
CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
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| InChI |
1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
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| InChIKey |
AKCRNFFTGXBONI-UHFFFAOYSA-N
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| CAS Number |
CAS 1222998-36-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
103911693, 121134601, 121284527, 123085155, 123107699, 135686236, 135686237, 135686246, 135686247, 137276059, 138891018, 152159673, 152258410, 160647247, 162011620, 162205134, 163975180, 164234660, 164765660, 170481036, 172919745, 174006448, 174526742, 180189117, 185971945, 223390975, 223736474, 233479270, 241376887, 245695843, 249565684, 251910606, 252109945, 252157907, 252160492, 252216488, 252446824, 252451569
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| ChEBI ID |
CHEBI:84327
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| References | Top | |||
|---|---|---|---|---|
| REF 1 | An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009 Mar 20;284(12):8023-32. | |||
| REF 2 | Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 2010 Oct 14;53(19):7146-55. | |||
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