Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H2DQ
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Former ID |
DAP000916
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Drug Name |
Probucol
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Synonyms |
Biphenabid; Bisbid; Bisphenabid; Lesterol; Lorelco; Lursell; Lurselle; Panavir; Probucolum; Sinlestal; Superlipid; Almirall Brand of Probucol; Aventis Brand of Probucol; Hoechst Brand of Probucol; DH 581; DH581; DE-3872; DH-581; LORELCO (TN); Probucolum [INN-Latin]; ZERO/001429; Probucol (JAN/USP/INN); Probucol [USAN:BAN:INN:JAN]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol; 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]; 4,4'-(Isopropylidenedithio)bis[2,6-di-tert-butylphenol]; 4,4'-(propane-2,2-diyldisulfanediyl)bis(2,6-di-tert-butylphenol); 4,4'-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]
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Drug Type |
Small molecular drug
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Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1, I25.4] | Approved | [1], [2] | |
Therapeutic Class |
Anticholesteremic Agents
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Structure |
Download2D MOL |
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Formula |
C31H48O2S2
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Canonical SMILES |
CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
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InChI |
1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
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InChIKey |
FYPMFJGVHOHGLL-UHFFFAOYSA-N
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CAS Number |
CAS 23288-49-5
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PubChem Compound ID | ||||
PubChem Substance ID |
9577, 123183, 505620, 611407, 1916626, 3221724, 5227619, 7734994, 7847542, 7980386, 8139943, 8149708, 8153023, 10321432, 11112687, 11335774, 11361013, 11364190, 11364806, 11366752, 11367368, 11369314, 11369930, 11372495, 11372970, 11373847, 11375530, 11377476, 11378097, 11461985, 11466412, 11467532, 11485156, 11486224, 11489216, 11491253, 11492229, 11495110, 12014197, 14933920, 24899054, 26612166, 26680968, 26748484, 26748485, 29223990, 46508876, 47291113, 47515308, 47662268
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ChEBI ID |
CHEBI:8427
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SuperDrug ATC ID |
C10AX02
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SuperDrug CAS ID |
cas=023288495
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Target and Pathway | Top | |||
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Target(s) | ATP-binding cassette transporter A1 (ABCA1) | Target Info | Modulator | [3] |
KEGG Pathway | ABC transporters | |||
Fat digestion and absorption | ||||
NetPath Pathway | Leptin Signaling Pathway | |||
Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptor | |||
Reactome | HDL-mediated lipid transport | |||
PPARA activates gene expression | ||||
WikiPathways | Statin Pathway | |||
Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
Lipid digestion, mobilization, and transport | ||||
SREBF and miR33 in cholesterol and lipid homeostasis | ||||
Folate Metabolism | ||||
Vitamin B12 Metabolism | ||||
Selenium Micronutrient Network |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7277). | |||
REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017535. | |||
REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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