Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H5KO
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Former ID |
DIB009784
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Drug Name |
KW-3635
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Synonyms |
KW-3635; GTPL1977; KW3635
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Drug Type |
Small molecular drug
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Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Discontinued in Phase 1 | [1], [2] | |
Company |
Kyowa Hakko Kogyo Co Ltd
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Structure |
Download2D MOL
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Formula |
C26H21N2NaO3
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Canonical SMILES |
CC1=CC2=C(C=C1C)N(C=N2)CC=C3C4=CC=CC=C4COC5=C3C=C(C=C5)C(=O)[O-].[Na+]
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InChI |
1S/C26H22N2O3.Na/c1-16-11-23-24(12-17(16)2)28(15-27-23)10-9-21-20-6-4-3-5-19(20)14-31-25-8-7-18(26(29)30)13-22(21)25;/h3-9,11-13,15H,10,14H2,1-2H3,(H,29,30);/q;+1/p-1/b21-9+;
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InChIKey |
KWELWDMCBFWKQN-CSFJJMQLSA-M
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CAS Number |
CAS 127166-41-0
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Thromboxane A2 receptor (TBXA2R) | Target Info | Antagonist | [3] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Platelet activation | ||||
Reactome | Prostanoid ligand receptors | |||
G alpha (q) signalling events | ||||
G alpha (12/13) signalling events | ||||
Thromboxane signalling through TP receptor | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Small Ligand GPCRs | ||||
Signal amplification | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1977). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000338) | |||
REF 3 | Antithrombotic effects of KW-3635, a thromboxane A2-receptor antagonist, in guinea pigs. Jpn J Pharmacol. 1994 Jun;65(2):93-8. |
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