Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H5TU
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Former ID |
DIB004048
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Drug Name |
RQ-00000008
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Synonyms |
CJ-042794; Prostaglandin EP4 antagonists (chronic inflammatory pain), Pfizer; Prostaglandin EP4 antagonists (chronic inflammatory pain), RaQualia
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Drug Type |
Small molecular drug
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Indication | Inflammation [ICD-11: 1A00-CA43.1] | Investigative | [1] | |
Company |
Pfizer Inc
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Structure |
Download2D MOL |
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Formula |
C22H17ClFNO4
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Canonical SMILES |
CC(C1=CC=C(C=C1)C(=O)O)NC(=O)C2=C(C=CC(=C2)Cl)OC3=CC=C(C=C3)F
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InChI |
1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1
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InChIKey |
MWBNCZHVEXULBD-ZDUSSCGKSA-N
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CAS Number |
CAS 847728-01-2
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Prostaglandin E2 receptor EP4 (PTGER4) | Target Info | Antagonist | [2] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Inflammatory mediator regulation of TRP channels | ||||
Renin secretion | ||||
Pathways in cancer | ||||
NetPath Pathway | FSH Signaling Pathway | |||
IL2 Signaling Pathway | ||||
IL4 Signaling Pathway | ||||
TGF_beta_Receptor Signaling Pathway | ||||
Reactome | Prostanoid ligand receptors | |||
G alpha (s) signalling events | ||||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
GPCRs, Class A Rhodopsin-like | ||||
Vitamin D Receptor Pathway | ||||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5857). | |||
REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343). |
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