Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H6PN
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Former ID |
DIB006078
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Drug Name |
LORECLEZOLE
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Synonyms |
Loreclezole < Rec INN; R-72063; (Z)-1-(alpha,2,4-Trichlorostyryl)-1H-1,2,4-triazole; (Z)-1-[2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1H-1,2,4-triazole
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Drug Type |
Small molecular drug
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Indication | Epileptic seizures [ICD-11: 8A61-8A6Z; ICD-9: 345.9, 780.3] | Discontinued in Phase 2 | [1], [2] | |
Structure |
Download2D MOL |
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Formula |
C10H6Cl3N3
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Canonical SMILES |
C1=CC(=C(C=C1Cl)Cl)C(=CN2C=NC=N2)Cl
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InChI |
1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-
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InChIKey |
XGLHZTBDUXXHOM-WMZJFQQLSA-N
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CAS Number |
CAS 117857-45-1
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:92491
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Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor gamma-3 (GABRG3) | Target Info | Modulator | [3] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5466). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007906) | |||
REF 3 | Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35(12):1753-60. |
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