Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0H8AW
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| Former ID |
DNC004816
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| Drug Name |
GNF-PF-607
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| Synonyms |
GNF-PF-607; CHEMBL113999; 13794-67-7; N6-[(3,4,5-trimethoxyphenyl)methyl]quinazoline-2,4,6-triamine; NSC156246; AC1L6FHM; AC1Q4YN2; n6-(3,4,5-trimethoxybenzyl)quinazoline-2,4,6-triamine; CTK0I1910; DTXSID70303050; BDBM50066492; NSC-156246; 6-[(3,4,5-Trimethoxybenzyl)amino]quinazoline-2,4-diamine; N*6*-(3,4,5-Trimethoxy-benzyl)-quinazoline-2,4,6-triamine; 6-N-[(3,4,5-trimethoxyphenyl)methyl]quinazoline-2,4,6-triamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H21N5O3
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)CNC2=CC3=C(C=C2)N=C(N=C3N)N
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| InChI |
1S/C18H21N5O3/c1-24-14-6-10(7-15(25-2)16(14)26-3)9-21-11-4-5-13-12(8-11)17(19)23-18(20)22-13/h4-8,21H,9H2,1-3H3,(H4,19,20,22,23)
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| InChIKey |
YYJWQABXDCUJEF-UHFFFAOYSA-N
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| CAS Number |
CAS 13794-67-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate r... J Med Chem. 2005 Mar 10;48(5):1448-69. | |||
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