Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0H8OH
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| Former ID |
DIB014142
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| Drug Name |
Palovarotene
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| Synonyms |
R-667; RG-667; Retinoid receptor agonist, Roche; Ro-3300074; Ro-330074
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| Drug Type |
Small molecular drug
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| Indication | Fibrodysplasia ossificans progressiva [ICD-11: FB31.1; ICD-10: M61.1] | Approved | [1] | |
| Emphysema [ICD-11: CA21; ICD-9: 492] | Phase 2 | [2], [3] | ||
| Company |
Ipsen; Roche
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| Structure |
 |
Download2D MOL |
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| Formula |
C27H30N2O2
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| Canonical SMILES |
CC1(CCC(C2=C1C=C(C(=C2)C=CC3=CC=C(C=C3)C(=O)O)CN4C=CC=N4)(C)C)C
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| InChI |
1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
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| InChIKey |
YTFHCXIPDIHOIA-DHZHZOJOSA-N
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| CAS Number |
CAS 410528-02-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor gamma (RARG) | Target Info | Agonist | [1] |
| Reactome | Nuclear Receptor transcription pathway | |||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Nuclear Receptors in Lipid Metabolism and Toxicity | ||||
| Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | ||||
| Nuclear Receptors | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 215559 | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8276). | |||
| REF 3 | Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor. Eur Respir J. 2012 Aug;40(2):306-12. | |||
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