Drug Information
Drug General Information | Top | |||
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Drug ID |
D0H9QC
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Former ID |
DCL001236
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Drug Name |
S-474474
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Indication | Metabolic syndrome x [ICD-11: 5C50-5D2Z; ICD-10: E88.81; ICD-9: 277.7] | Phase 3 | [1] | |
Company |
Shionogi
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Target and Pathway | Top | |||
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Target(s) | Angiotensin II receptor type-1 (AGTR1) | Target Info | Blocker | [1] |
KEGG Pathway | Calcium signaling pathway | |||
cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Adrenergic signaling in cardiomyocytes | ||||
Vascular smooth muscle contraction | ||||
Renin-angiotensin system | ||||
Renin secretion | ||||
Pathways in cancer | ||||
NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
Panther Pathway | Angiotensin II-stimulated signaling through G proteins and beta-arrestin | |||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Muscle/Heart Contraction | ||||
Pathway Interaction Database | Arf6 trafficking events | |||
Arf6 signaling events | ||||
Angiopoietin receptor Tie2-mediated signaling | ||||
Reactome | Peptide ligand-binding receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | ACE Inhibitor Pathway | |||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Peptide GPCRs | ||||
Allograft Rejection | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Clinical pipeline report, company report or official report of Shionogi (2011). |
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