Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0I2WV
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| Former ID |
DIB007458
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| Drug Name |
Levamlodipine
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| Synonyms |
Levamlodipine (hypertension); S-amlodipine gentisate; Levamlodipine (hypertension), SK Chemicals; S-amlodipine (hypertension), SK Chemicals
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Phase 4 | [1], [2] | |
| Company |
SK Chemicals Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C20H25ClN2O5
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| Canonical SMILES |
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
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| InChI |
1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1
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| InChIKey |
HTIQEAQVCYTUBX-KRWDZBQOSA-N
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| CAS Number |
CAS 103129-82-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:53796
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated L-type calcium channel (L-CaC) | Target Info | Modulator | [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01131546) Efficacy and Safety of Levamlodipine Besylate Compared to Amlodipine Maleate in Patients With Essential Hypertension. U.S. National Institutes of Health. | |||
| REF 2 | Quantification of pedal edema during treatment with S(-)-amlodipine nicotinate versus amlodipine besylate in female Korean patients with mild to moderate hypertension: a 12-week, multicenter, randomized, double-blind, active-controlled, phase IV clinical trial. Clin Ther. 2012 Sep;34(9):1940-7. | |||
| REF 3 | Effects of (S)-amlodipine and (R)-amlodipine on L-type calcium channel current of rat ventricular myocytes and cytosolic calcium of aortic smooth muscle cells. Pharmazie. 2008 Jun;63(6):470-4. | |||
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