Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0I4ZN
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| Former ID |
DIB012539
|
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| Drug Name |
GSK2879552
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| Indication | Small-cell lung cancer [ICD-11: 2C25.Y; ICD-9: 162.9] | Phase 1 | [1] | |
| Company |
Glaxosmithkline
|
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| Structure |
 |
Download2D MOL |
||
| Formula |
C23H28N2O2
|
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| Canonical SMILES |
C1CN(CCC1CNC2CC2C3=CC=CC=C3)CC4=CC=C(C=C4)C(=O)O
|
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| InChI |
1S/C23H28N2O2/c26-23(27)20-8-6-18(7-9-20)16-25-12-10-17(11-13-25)15-24-22-14-21(22)19-4-2-1-3-5-19/h1-9,17,21-22,24H,10-16H2,(H,26,27)/t21-,22+/m0/s1
|
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| InChIKey |
LRULVYSBRWUVGR-FCHUYYIVSA-N
|
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| CAS Number |
CAS 1401966-69-5
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Lysine-specific histone demethylase 1 (LSD) | Target Info | Inhibitor | [2] |
| Pathway Interaction Database | Notch signaling pathway | |||
| Coregulation of Androgen receptor activity | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | HDACs deacetylate histones | |||
| Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||||
| Factors involved in megakaryocyte development and platelet production | ||||
| WikiPathways | Factors involved in megakaryocyte development and platelet production | |||
| Androgen receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02034123) Investigation of GSK2879552 in Subjects With Relapsed/Refractory Small Cell Lung Carcinoma. U.S. National Institutes of Health. | |||
| REF 2 | A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC. Cancer Cell. 2015 Jul 13;28(1):57-69. | |||
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