Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0IX1A
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| Former ID |
DAP001144
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| Drug Name |
Pentolinium
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| Synonyms |
Pentolineum; Pentolonium; Pentolonum; 1,1'-pentane-1,5-diylbis(1-methylpyrrolidinium); 1-methyl-1-[5-(1-methylpyrrolidin-1-ium-1-yl)pentyl]pyrrolidin-1-ium
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| Drug Type |
Small molecular drug
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| Indication | Hypotension [ICD-11: BA20-BA21] | Approved | [1] | |
| Therapeutic Class |
Antihypertensive Agents
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| Company |
Wyeth Ayerst Laboratories
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H32N2+2
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| Canonical SMILES |
C[N+]1(CCCC1)CCCCC[N+]2(CCCC2)C
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| InChI |
1S/C15H32N2/c1-16(12-6-7-13-16)10-4-3-5-11-17(2)14-8-9-15-17/h3-15H2,1-2H3/q+2
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| InChIKey |
XSBSKEQEUFOSDD-UHFFFAOYSA-N
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| CAS Number |
CAS 144-44-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:347401
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-4 (CHRNA4) | Target Info | Antagonist | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Cholinergic synapse | ||||
| Nicotine addiction | ||||
| Panther Pathway | Nicotinic acetylcholine receptor signaling pathway | |||
| Nicotine pharmacodynamics pathway | ||||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| Highly calcium permeable nicotinic acetylcholine receptors | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Pentolinium, 2008. eduDrugs. | |||
| REF 2 | Nicotinic and nonnicotinic receptor-mediated actions of vinblastine. Proc Soc Exp Biol Med. 1993 Jul;203(3):372-6. | |||
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