Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0J0JC
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| Former ID |
DIB001121
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| Drug Name |
FRG-8701
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| Synonyms |
FRG8701; 108498-50-6; Acetamide,2-[(2-furanylmethyl)sulfinyl]-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-; Frg 8701; Frg-8701; ACMC-20mbjv; AC1L2WUW; SCHEMBL5083014; CTK4A6065; IWLUMUDDKHJJPB-UHFFFAOYSA-N; HY-U00238; AKOS030565773; N-(3-(3-(Piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide; CS-7405; L002080; N-{3-[3-(piperidinomethyl)phenoxy] propyl]-2-(furfurylsulfinyl) acetamide; Acetamide, 2-((2-furanylmethyl)sulfinyl)-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-
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| Drug Type |
Small molecular drug
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| Indication | Stomach ulcer [ICD-11: DA60.Z; ICD-10: K25-K27] | Terminated | [1] | |
| Company |
Fujirebio KK
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H30N2O4S
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| Canonical SMILES |
C1CCN(CC1)CC2=CC(=CC=C2)OCCCNC(=O)CS(=O)CC3=CC=CO3
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| InChI |
1S/C22H30N2O4S/c25-22(18-29(26)17-21-9-5-13-28-21)23-10-6-14-27-20-8-4-7-19(15-20)16-24-11-2-1-3-12-24/h4-5,7-9,13,15H,1-3,6,10-12,14,16-18H2,(H,23,25)
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| InChIKey |
IWLUMUDDKHJJPB-UHFFFAOYSA-N
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| CAS Number |
CAS 108498-50-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Modulator | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. | |||
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