Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0K0WK
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| Former ID |
DNC009535
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| Drug Name |
NSC-341622
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| Synonyms |
66358-49-4; UNII-Q1G3FJ6TLS; NSC314622; Q1G3FJ6TLS; MLS002701805; NSC-314622; 2,3-Dimethoxy-6-methyl-5H-(1,3)dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione; NSC 314622; 2,3-Dimethoxy-6-methyl-5H-[1,3]dioxolo[4',5':5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione; NSC-341622; NCIMech_000446; AC1L75KV; CHEMBL79513; SCHEMBL14147251; CTK5C4398; DTXSID40216582; ZINC1570831; CCG-35623; SMR001565399; NCI60_002710; 5H-[1,6]indeno[1,2-c]isoquinoline-5,12-dione, 2,3-dimethoxy-6-methyl-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C20H15NO6
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| Canonical SMILES |
CN1C2=C(C3=CC(=C(C=C3C1=O)OC)OC)C(=O)C4=CC5=C(C=C42)OCO5
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| InChI |
1S/C20H15NO6/c1-21-18-10-5-15-16(27-8-26-15)6-11(10)19(22)17(18)9-4-13(24-2)14(25-3)7-12(9)20(21)23/h4-7H,8H2,1-3H3
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| InChIKey |
LWLNFIXOPOZENE-UHFFFAOYSA-N
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| CAS Number |
CAS 66358-49-4
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [1] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of share... Bioorg Med Chem. 2009 Oct 15;17(20):7145-55. | |||
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