Drug Information
Drug General Information | Top | |||
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Drug ID |
D0K1FG
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Former ID |
DNC011339
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Drug Name |
8-Acetyl-7-hydroxy-2H-chromen-2-one
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Synonyms |
8-Acetyl-7-hydroxycoumarin; 6748-68-1; 8-acetyl-7-hydroxy-2H-chromen-2-one; 7-hydroxy-8-acetylcoumarin; CHEMBL446518; AN-829/13872055; AC1NTTTW; SCHEMBL4639845; CTK5C6237; 8-acetyl-7-hydroxychromen-2-one; DTXSID40419935; MolPort-003-821-703; 8-acetyl-7-hydroxy-2-oxochromene; ZINC366861; 8-acetyl-7-hydroxy-chromen-2-one; 8-Acetyl-7-hydroxycoumarin, 97%; BDBM50332038; MFCD00270162; 8 - Acetyl - 7 - hydroxycoumarin; AKOS022647720; OR345001; KB-200256; ST50309088; Z3067; 2H-1-Benzopyran-2-one, 8-acetyl-7-hydroxy-
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C11H8O4
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Canonical SMILES |
CC(=O)C1=C(C=CC2=C1OC(=O)C=C2)O
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InChI |
1S/C11H8O4/c1-6(12)10-8(13)4-2-7-3-5-9(14)15-11(7)10/h2-5,13H,1H3
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InChIKey |
XWYMACPLPPQCHC-UHFFFAOYSA-N
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CAS Number |
CAS 6748-68-1
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] |
KEGG Pathway | Nitrogen metabolism | |||
Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
Reactome | Regulation of gene expression by Hypoxia-inducible Factor | |||
Reversible hydration of carbon dioxide | ||||
WikiPathways | Vitamin D Receptor Pathway | |||
Reversible Hydration of Carbon Dioxide | ||||
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
References | Top | |||
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REF 1 | 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. |
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