Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L0MO
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Former ID |
DIB004340
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Drug Name |
Satigrel
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Synonyms |
E-5510
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Drug Type |
Small molecular drug
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Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Discontinued in Preregistration | [1] | |
Company |
Eisai Co Ltd
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Structure |
Download2D MOL |
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Formula |
C20H19NO4
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Canonical SMILES |
COC1=CC=C(C=C1)C(=C(CCC(=O)O)C#N)C2=CC=C(C=C2)OC
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InChI |
1S/C20H19NO4/c1-24-17-8-3-14(4-9-17)20(16(13-21)7-12-19(22)23)15-5-10-18(25-2)11-6-15/h3-6,8-11H,7,12H2,1-2H3,(H,22,23)
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InChIKey |
GRVCTHTXJDYIHB-UHFFFAOYSA-N
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CAS Number |
CAS 111753-73-2
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Thromboxane-A synthase (TBXAS1) | Target Info | Modulator | [2] |
BioCyc | C20 prostanoid biosynthesis | |||
KEGG Pathway | Arachidonic acid metabolism | |||
Metabolic pathways | ||||
Platelet activation | ||||
Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
WikiPathways | Prostaglandin Synthesis and Regulation | |||
Arachidonic acid metabolism | ||||
Phase 1 - Functionalization of compounds | ||||
Eicosanoid Synthesis |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000441) | |||
REF 2 | Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33. |
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