Drug Information
Drug General Information | Top | |||
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Drug ID |
D0L2AO
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Former ID |
DNC014893
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Drug Name |
DIHYDROXANTHOHUMOL
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Synonyms |
dihydroxanthohumol; alpha,beta-dihydroxanthohumol; MLS000863606; 4,2',4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone; CHEBI:66332; SMR000440746; a,b-Dihydroxanthohumol; MEGxp0_001797; CHEMBL510279; SCHEMBL15704299; BDBM76566; ACon1_000059; cid_10450920; HMS2267A19; LMPK12120536; 1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)propan-1-one; NCGC00168833-01; BRD-K15951006-001-01-4; 2',4,4'-Trihydroxy-6'-methoxy-3'-prenyldihydrochalcone
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C21H24O5
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Canonical SMILES |
CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)CCC2=CC=C(C=C2)O)O)C
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InChI |
1S/C21H24O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-6,8-9,12,22,24-25H,7,10-11H2,1-3H3
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InChIKey |
SVTCZHIDEDUTBH-UHFFFAOYSA-N
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CAS Number |
CAS 102448-00-0
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PubChem Compound ID | ||||
ChEBI ID |
CHEBI:66332
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Target and Pathway | Top | |||
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Target(s) | Calpain-2 (CAPN2) | Target Info | Inhibitor | [1] |
KEGG Pathway | Protein processing in endoplasmic reticulum | |||
Apoptosis | ||||
Alzheimer's disease | ||||
Reactome | Degradation of the extracellular matrix | |||
WikiPathways | Focal Adhesion | |||
Integrated Pancreatic Cancer Pathway | ||||
Alzheimers Disease | ||||
Integrin-mediated Cell Adhesion |
References | Top | |||
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REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. |
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