Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L3XV
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| Former ID |
DIB016880
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| Drug Name |
SMART anti-E/P selectin
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| Synonyms |
HuEP5C7; Bispecific anti-E/P selectin, PDL; SMART anti-E/P selectin, PDL; SMART anti-E/P selectin, Protein Design Labs; Anti-E/P selectin (humanized), PDL
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Discontinued in Phase 1 | [1] | |
| Company |
PDL BioPharma Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | E-selectin (SELE) | Target Info | Modulator | [2] |
| P-selectin (SELP) | Target Info | Modulator | [2] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Malaria | ||||
| Staphylococcus aureus infection | ||||
| TNF signaling pathway | ||||
| African trypanosomiasis | ||||
| NetPath Pathway | IL5 Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| TNFalpha Signaling Pathway | ||||
| ID Signaling Pathway | ||||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| amb2 Integrin signaling | ||||
| Thromboxane A2 receptor signaling | ||||
| Glucocorticoid receptor regulatory network | ||||
| ATF-2 transcription factor network | ||||
| Reactome | Platelet degranulation | |||
| Cell surface interactions at the vascular wall | ||||
| WikiPathways | Human Complement System | |||
| Spinal Cord Injury | ||||
| Cell surface interactions at the vascular wall | ||||
| TNF alpha Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008129) | |||
| REF 2 | HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke. Circ Res. 2002 Nov 15;91(10):907-14. | |||
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