Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0LO5B
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| Former ID |
DIB021056
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| Drug Name |
THZ1
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| Synonyms |
HY-80013
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| Drug Type |
Small molecular drug
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| Indication | Nasopharyngeal carcinoma [ICD-11: 2B6B; ICD-9: 147] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C31H28ClN7O2
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| Canonical SMILES |
CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
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| InChI |
1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+
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| InChIKey |
OBJNFLYHUXWUPF-IZZDOVSWSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.Cancer Res. 2017 Dec 1;77(23):6614-6626. | |||
| REF 2 | Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. | |||
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