Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0M3QP
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| Former ID |
DAP000120
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| Drug Name |
Digitoxin
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| Synonyms |
Acedoxin; Asthenthilo; Cardidigin; Cardigin; Cardiolanata; Carditalin; Carditoxin; Coramedan; Cristapurat; Crystodigin; Digicor; Digilanid; Digilong; Digimed; Digimerck; Digipural; Digisidin; Digitoksim; Digitoksin; Digitophyllin; Digitossina; Digitoxina; Digitoxine; Digitoxinum; Digitoxoside; Digitoxosidum; Digitrin; Ditaven; Glucodigin; Lanatoxin; Lanostabil; Monodigitoxoside; Myodigin; Natigal; Pandigal; Panlanat; Purodigin; Purpurid; Tardigal; Unidigin; Crystalline digitalin; Digitaline cristallisee; Digitaline nativelle; Digitalinum verum; Digitossina [DCIT]; Digitoxigenin tridigitoxoside; LT00244784; Crystodigin (TN); De-Tone; Digitalin, crystalline; Digitaline (TN); Digitoxigenin-tridigitoxosid; Digitoxigenin-tridigitoxosid [German]; Digitoxina [INN-Spanish]; Digitoxine [INN-French]; Digitoxinum [INN-Latin]; Mono-digitoxid; Mono-digitoxid [German]; Mono-glycocard; Purodigin, crystalline; Tri-digitoxoside; Tri-digitoxoside [German]; Digitoxin [INN:BAN:JAN]; Digitoxin (JP15/USP/INN); Inhibits Na+/K+ ATPase; 5.beta.-Card-20(22)-enolide, 3.beta.,14-dihydroxy-, 3-[tris-(digitoxoside)]
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| Drug Type |
Small molecular drug
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| Indication | Arrhythmia [ICD-11: BC9Z] | Approved | [1], [2], [3] | |
| Congestive cardiac insufficiency [ICD-11: BD1Z; ICD-10: I50, I50.9] | Approved | [1], [2], [3] | ||
| Heart failure [ICD-11: BD10-BD13] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Antiarrhythmic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C41H64O13
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| Canonical SMILES |
CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CCC7(C6(CCC7C8=CC(=O)OC8)O)C)C)C)C)O)O
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| InChI |
1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27+,28-,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
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| InChIKey |
WDJUZGPOPHTGOT-XUDUSOBPSA-N
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| CAS Number |
CAS 71-63-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9170, 3139545, 7847363, 7979082, 10298760, 11533060, 12015761, 14889043, 16335905, 24434759, 24893976, 26754429, 29204037, 36885098, 46506035, 47349645, 48169692, 48318721, 48394206, 48415893, 48496158, 50109842, 50333813, 53787897, 57287891, 57403584, 85300744, 85842716, 87567202, 92298457, 103556970, 104624909, 124573763, 127284350, 127284351, 127303961, 127303962, 127303963, 127303964, 127303965, 127303966, 127303967, 127303968, 127303969, 127303970, 134337444, 134972304, 135377837, 135756584, 137004198
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| ChEBI ID |
CHEBI:28544
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| SuperDrug ATC ID |
C01AA04
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| SuperDrug CAS ID |
cas=000071636
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.355; p = 0.001). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.557; p = 0.0). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.421; p = 0.005). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.903; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.826; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.74; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.54; p = 0.0). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.553; p = 0.002). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.672; p = 0.007). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.394; p = 0.001). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.423; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.338; p = 0.003). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.433; p = 0.017). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.611; p = 0.0). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.557; p = 0.004). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.475; p = 0.001). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Odoribacter splanchnicus (log2FC = -0.524; p = 0.0). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.35; p = 0.011). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.659; p = 0.009). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.396; p = 0.009). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.433; p = 0.022). | |||
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Studied Microbe: Clostridium sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Clostridium sp. (log2FC = -0.382; p = 0.002). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Digitoxin can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -0.342; p = 0.012). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [5], [6] | |||
| Microbial Enzyme | Beta glucuronidase | |||
| Metabolic Reaction | Hydrolysis | |||
| Description | Digitoxin can be metabolized by the beta glucuronidase of gut microbiota through hydrolysis. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6782). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10461-10466. | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | The fate of a major biliary metabolite of digitoxin in the rat intestine. Drug Metab Dispos. 1978 Jul-Aug;6(4):418-24. | |||
| REF 6 | Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes. Curr Drug Metab. 2019;20(2):155-165. | |||
| REF 7 | Treatment of congestive heart failure--current status of use of digitoxin. Eur J Clin Invest. 2001;31 Suppl 2:10-7. | |||
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