Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N0TZ
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| Former ID |
DIB005125
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| Drug Name |
Clopidogrel
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| Synonyms |
clopidogrel; 113665-84-2; (S)-Clopidogrel; Plavix; Clopidogrel [INN:BAN]; (+)-(S)-Clopidogrel; (+)-Clopidogrel; UNII-A74586SNO7; HSDB 7430; CLOPIDOGREL SULFATE; CHEBI:37941; GKTWGGQPFAXNFI-HNNXBMFYSA-N; A74586SNO7; CPD000550475; Zyllt; Clopidogrel (TN); SR-25990C; Plavix (TN); methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanoate; Clopidogrelum; Thrombo; Clopidogrel BMS; Clopidogrel Hexal; Clopidogrel Acino; methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate; PM-103; Clopidogrel (captisol-enabled); Clopidogrel (captisol-enabled), The Medicines Co; Clopidogrel (captisol-enabled, cardiovascular disease), Cydex; Clopidogrel (captisol-enabled, cardiovascular disease), Prism Pharmaceuticals
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| Drug Type |
Small molecular drug
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| Indication | Thrombosis [ICD-11: DB61-GB90; ICD-10: I80-I82] | Approved | [1], [2], [3] | |
| Company |
Prism Pharmaceuticals Inc
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| Structure |
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Download2D MOL |
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| Formula |
C16H16ClNO2S
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| Canonical SMILES |
COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3
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| InChI |
1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
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| InChIKey |
GKTWGGQPFAXNFI-HNNXBMFYSA-N
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| CAS Number |
CAS 113665-84-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7978975, 8150041, 8186960, 11335962, 11361201, 11362959, 11365521, 11368083, 11372530, 11373828, 11376245, 11462173, 11484199, 11488328, 11491421, 11491990, 11493919, 14899359, 14923888, 43117983, 46507295, 47365229, 48035158, 48415808, 49666065, 49666423, 49830418, 50064182, 50111396, 50139266, 50300054, 51092025, 56320467, 85787400, 89736084, 92309297, 92309332, 92717149, 93166442, 93625433, 99301875, 99309408, 103724173, 104153271, 104170201, 104178839, 104321200, 117481059, 117776384, 121362382
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| ChEBI ID |
CHEBI:37941
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| ADReCS Drug ID | BADD_D00504 ; BADD_D00505 | |||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides coprophilus DSM 18228
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides coprophilus DSM 18228 (log2FC = -0.324; p = 0.003). | |||
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Studied Microbe: Bacteroides dorei DSM 17855
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.638; p = 0.001). | |||
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Studied Microbe: Bacteroides eggerthii DSM20697
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides eggerthii DSM20697 (log2FC = -0.407; p = 0.003). | |||
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Studied Microbe: Bacteroides fragilis ATCC43859
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis ATCC43859 (log2FC = -0.972; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 610
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis HMW 610 (log2FC = -0.818; p = 0.001). | |||
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Studied Microbe: Bacteroides fragilis HMW 615
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis HMW 615 (log2FC = -0.791; p = 0.02). | |||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.368; p = 0.007). | |||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.605; p = 0.004). | |||
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Studied Microbe: Bacteroides fragilis str. 3986 T(B)9
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis str. 3986 T(B)9 (log2FC = -0.654; p = 0.0). | |||
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Studied Microbe: Bacteroides fragilis str. DS-208
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides fragilis str. DS-208 (log2FC = -0.69; p = 0.003). | |||
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Studied Microbe: Bacteroides ovatus ATCC 8483
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides ovatus ATCC 8483 (log2FC = -0.366; p = 0.006). | |||
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Studied Microbe: Bacteroides stercoris ATCC 43183
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides stercoris ATCC 43183 (log2FC = -0.433; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron 7330
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides thetaiotaomicron 7330 (log2FC = -0.416; p = 0.001). | |||
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Studied Microbe: Bacteroides thetaiotaomicron VPI-5482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides thetaiotaomicron VPI-5482 (log2FC = -0.464; p = 0.006). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.597; p = 0.0). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.624; p = 0.003). | |||
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Studied Microbe: Bacteroides xylanisolvens DSM18836
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Bacteroides xylanisolvens DSM18836 (log2FC = -0.46; p = 0.001). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Odoribacter splanchnicus (log2FC = -0.522; p = 0.001). | |||
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Studied Microbe: Parabacteroides distasonis ATCC 8503
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -0.341; p = 0.006). | |||
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Studied Microbe: Parabacteroides johnsonii DSM 18315
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Parabacteroides johnsonii DSM 18315 (log2FC = -0.561; p = 0.01). | |||
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Studied Microbe: Parabacteroides merdae ATCC 43184
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Parabacteroides merdae ATCC 43184 (log2FC = -0.361; p = 0.008). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.419; p = 0.002). | |||
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Studied Microbe: Clostridium sp.
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Clostridium sp. (log2FC = -0.42; p = 0.002). | |||
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Studied Microbe: Clostridium sporogenes ATCC 15579
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[4] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Clopidogrel sulfate can be metabolized by Clostridium sporogenes ATCC 15579 (log2FC = -0.327; p = 0.011). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | P2Y purinoceptor 12 (P2RY12) | Target Info | Antagonist | [3], [5] |
| KEGG Pathway | Platelet activation | |||
| Reactome | P2Y receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Signal amplification | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7150). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029432) | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328). | |||
| REF 4 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 5 | P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22. | |||
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