Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N1YW
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| Former ID |
DNC005783
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| Drug Name |
GNF-PF-2322
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| Synonyms |
GNF-PF-2322; CHEMBL194986; SR-01000548998
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C26H26N4O3
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| Canonical SMILES |
CCN1CCN(CC1)C2=NC3=C(C=C(C=C3)NC(=O)C4=CC(=O)C5=CC=CC=C5O4)C(=C2)C
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| InChI |
1S/C26H26N4O3/c1-3-29-10-12-30(13-11-29)25-14-17(2)20-15-18(8-9-21(20)28-25)27-26(32)24-16-22(31)19-6-4-5-7-23(19)33-24/h4-9,14-16H,3,10-13H2,1-2H3,(H,27,32)
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| InChIKey |
GDOKGIIKPLGRMR-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Melanin-concentrating hormone receptor 1 (MCHR1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and ... J Med Chem. 2005 Sep 8;48(18):5684-97. | |||
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