Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O0AI
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| Former ID |
DNC002829
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| Drug Name |
6-Carboxymethyluracil
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| Synonyms |
6-Carboxymethyluracil; 4628-39-1; URACIL-6-ACETIC ACID; Uracil-4-acetic acid; (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidineacetic acid; 2-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; uracil-6-ylacetic acid; NSC13201; 4-Pyrimidineacetic acid, 1,2,3,6-tetrahydro-2,6-dioxo-; (2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-acetic acid; CHEBI:46371; 2-(2,6-dihydroxypyrimidin-4-yl)acetic acid; 2-(2,4-dioxo-1H-pyrimidin-6-yl)acetic acid; 4-Pyrimidineaceticacid, 1,2,
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C6H6N2O4
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| Canonical SMILES |
C1=C(NC(=O)NC1=O)CC(=O)O
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| InChI |
1S/C6H6N2O4/c9-4-1-3(2-5(10)11)7-6(12)8-4/h1H,2H2,(H,10,11)(H2,7,8,9,12)
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| InChIKey |
NQAUNZZEYKWTHM-UHFFFAOYSA-N
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| CAS Number |
CAS 4628-39-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
77706, 630502, 821026, 4329868, 4913785, 8195645, 43129254, 46507113, 77519462, 88831413, 92149154, 93636690, 103717447, 103852167, 104354886, 108175846, 111978184, 117592894, 117609870, 125539387, 126922882, 127293379, 127293380, 127293381, 127293382, 131359425, 132524716, 135029706, 137185412, 139393193, 143445395, 152182722, 160966200, 162529043, 164848232, 164850710, 169427835, 172914647, 176255894, 179109172, 184578943, 186019192, 216310760, 218196703, 228247780, 247762202, 249504798, 249773207, 249773258, 252449353
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| ChEBI ID |
CHEBI:46371
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dihydrothymine dehydrogenase (DPYD) | Target Info | Inhibitor | [1] |
| BioCyc | Pyrimidine ribonucleosides degradation | |||
| Thymine degradation | ||||
| Uracil degradation | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| beta-Alanine metabolism | ||||
| Pantothenate and CoA biosynthesis | ||||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Panther Pathway | Pyrimidine Metabolism | |||
| Pathwhiz Pathway | Beta-Alanine Metabolism | |||
| Pyrimidine Metabolism | ||||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||
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