Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O0FF
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| Former ID |
DCL000126
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| Drug Name |
GW 468816
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| Synonyms |
GW468816; SCHEMBL5750612; CHEMBL1207366; (4e)-7-chloro-4-(2-oxo-1-phenyl-3-pyrrolidinylidene)-1,2,3,4-tetrahydro-2-quinolinecarboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Tobacco dependence [ICD-11: 6C4A.2; ICD-10: F17.2; ICD-9: 305.1] | Discontinued in Phase 2 | [1] | |
| Company |
GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C20H17ClN2O3
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| Canonical SMILES |
C1CN(C(=O)C1=C2CC(NC3=C2C=CC(=C3)Cl)C(=O)O)C4=CC=CC=C4
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| InChI |
1S/C20H17ClN2O3/c21-12-6-7-14-16(11-18(20(25)26)22-17(14)10-12)15-8-9-23(19(15)24)13-4-2-1-3-5-13/h1-7,10,18,22H,8-9,11H2,(H,25,26)/b16-15+
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| InChIKey |
XDKRVNKVAKCFGW-FOCLMDBBSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Glycine receptor (GlyR) | Target Info | Modulator | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Ligand-gated ion channel transport | |||
| WikiPathways | Iron uptake and transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Executive summary: nicotine addiction. Drugs Today (Barc). 2005 Jun;41(6):419-25. | |||
| REF 2 | A double-blind, placebo-controlled trial of the NMDA glycine site antagonist, GW468816, for prevention of relapse to smoking in females.J Clin Psychopharmacol.2011 Oct;31(5):597-602. | |||
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