Drug Information
Interaction between the Drug and Microbe | Top | |||
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The Metabolism of Drug Affected by Studied Microbe(s) | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Bacteroides dorei DSM 17855
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -1.188; p = 0.022). | |||
Studied Microbe: Bacteroides uniformis ATCC 8492
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.767; p = 0.017). | |||
Studied Microbe: Bacteroides vulgatus ATCC 8482
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.906; p = 0.008). | |||
Studied Microbe: Parabacteroides distasonis ATCC 8503
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Parabacteroides distasonis ATCC 8503 (log2FC = -1.37; p = 0.016). | |||
Studied Microbe: Pretovella copri DSM 18205
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Pretovella copri DSM 18205 (log2FC = -0.809; p = 0.021). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
Studied Microbe: Escherichia coli BW25113
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Escherichia coli BW25113 (log2FC = -1.081; p = 0.015). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Anaerostipes sp.
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Anaerostipes sp. (log2FC = -1.751; p = 0.039). | |||
Studied Microbe: Blautia hansenii DSM20583
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.555; p = 0.015). | |||
Studied Microbe: Eubacterium ventriosum ATCC 27560
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Eubacterium ventriosum ATCC 27560 (log2FC = -3.029; p = 0.008). | |||
Studied Microbe: Roseburia intestinalis L1-82
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[3] | |||
Hierarchy | ||||
Experimental Method | High-throughput screening | |||
Description | Fluphenazine can be metabolized by Roseburia intestinalis L1-82 (log2FC = -0.81; p = 0.042). | |||
The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
Studied Microbe: Parabacteroides distasonis
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Parabacteroides distasonis was decreased by Fluphenazine dihydrochloride (adjusted p-values: 5.57E-03). | |||
Studied Microbe: Prevotella copri
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Prevotella copri was decreased by Fluphenazine dihydrochloride (adjusted p-values: 1.60E-03). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Eubacterium rectale
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Fluphenazine dihydrochloride (adjusted p-values: 3.10E-03). | |||
Studied Microbe: Roseburia hominis
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia hominis was decreased by Fluphenazine dihydrochloride (adjusted p-values: 2.51E-03). | |||
Studied Microbe: Roseburia intestinalis
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[4] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia intestinalis was decreased by Fluphenazine dihydrochloride (adjusted p-values: 5.48E-03). |
Target and Pathway | Top | |||
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Target(s) | 5-HT 1B receptor (HTR1B) | Target Info | Modulator | [5] |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 204). | |||
REF 2 | The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain. Psychopharmacology (Berl). 2008 Jan;195(4):559-68. | |||
REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
REF 5 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. |
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