Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P8RS
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| Former ID |
DAP000634
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| Drug Name |
Proguanil
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| Synonyms |
Bigumal; Chlorguanid; Chlorguanide; Chloriguane; Chloroguanide; Paludrin; Proguanile; Proguanilum; Proguanile [DCIT]; Diguanyl (hydrochloride); Drinupal (hydrochloride); Paludrine (TN); Paludrine (hydrochloride); Palusil (hydrochloride); Proguanil [INN:BAN]; Proguanilum [INN-Latin]; RP-3359; Tirian (hydrochloride); M-4888 (hydrochloride); SN-12837 (hydrochloride); N1-p-Chlorophenyl-N5-isopropylbiguanide; N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide; N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide; N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide; (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine; 1-(p-Chlorophenyl)-5-isopropylbiguanide; 1-Isopropyl-5-(4-chlorophenyl)biguanide
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1] | |
| Therapeutic Class |
Antimalarials
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| Company |
AstraZeneca
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| Structure |
 |
Download2D MOL |
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| Formula |
C11H16ClN5
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| Canonical SMILES |
CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
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| InChI |
1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
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| InChIKey |
SSOLNOMRVKKSON-UHFFFAOYSA-N
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| CAS Number |
CAS 500-92-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9833, 603149, 7980396, 11112433, 11341938, 11362121, 11364482, 11367044, 11369606, 11372736, 11374343, 11377768, 11467027, 11468147, 11484765, 11486724, 11487523, 11488951, 11491474, 11492437, 11495402, 14823534, 47736673, 47885583, 47959951, 48035321, 48035322, 48185162, 48415754, 49698968, 49893807, 50100438, 50100439, 57309709, 57365545, 80043130, 85788592, 87246413, 93166734, 96025114, 103462237, 114370477, 134978163, 137004047, 137040200, 137131382, 160964465, 162188072, 175267378, 179039118
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| ChEBI ID |
CHEBI:8455
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| ADReCS Drug ID | BADD_D01853 | |||
| SuperDrug ATC ID |
P01BB01
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| SuperDrug CAS ID |
cas=000500925
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [2] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||
| REF 2 | Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10931-6. | |||
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