Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PR6H
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| Former ID |
DIB005563
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| Drug Name |
PENCLOMEDINE
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| Synonyms |
Penclomidine; CRC-88-04; 3,5-Dichloro-2,4-dimethoxy-6-(trichloromethyl)pyridine
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H6Cl5NO2
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| Canonical SMILES |
COC1=C(C(=NC(=C1Cl)OC)C(Cl)(Cl)Cl)Cl
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| InChI |
1S/C8H6Cl5NO2/c1-15-5-3(9)6(8(11,12)13)14-7(16-2)4(5)10/h1-2H3
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| InChIKey |
DZVPGIORVGSQMC-UHFFFAOYSA-N
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| CAS Number |
CAS 108030-77-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00002946) Penclomedine in Treating Patients With Solid Tumors or Lymphoma. U.S. National Institutes of Health. | |||
| REF 2 | The alkylating agent penclomedine induces degeneration of purkinje cells in the rat cerebellum. Invest New Drugs. 2003 Aug;21(3):269-79. | |||
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