Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q1PR
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| Former ID |
DAP000105
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| Drug Name |
Atracurium
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| Synonyms |
Atracurium Dibesylate; Tracrium (TN); 2,2'-{pentane-1,5-diylbis[oxy(3-oxopropane-3,1-diyl)]}bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium]; 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
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| Drug Type |
Small molecular drug
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| Indication | Anaesthesia [ICD-11: 9A78.6; ICD-9: 338] | Approved | [1] | |
| Therapeutic Class |
Neuromuscular Nondepolarizing Agents
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| Company |
Burroughs Wellcome Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C53H72N2O12+2
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| Canonical SMILES |
C[N+]1(CCC2=CC(=C(C=C2C1CC3=CC(=C(C=C3)OC)OC)OC)OC)CCC(=O)OCCCCCOC(=O)CC[N+]4(CCC5=CC(=C(C=C5C4CC6=CC(=C(C=C6)OC)OC)OC)OC)C
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| InChI |
1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2
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| InChIKey |
YXSLJKQTIDHPOT-UHFFFAOYSA-N
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| CAS Number |
CAS 64228-79-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9751, 7784964, 7978740, 8180170, 11467153, 11485666, 14938770, 34712331, 46504689, 47426512, 47575544, 47871876, 48396036, 49699403, 49987175, 50836729, 57313075, 87351879, 92309177, 103448799, 104037956, 104352644, 117582128, 126417939, 126422798, 126659069, 126685509, 129863303, 134337432, 135007403, 137234389, 140689099, 140713039, 142059844, 160844975, 160964076, 162189116, 176484291, 179150846, 196111914, 223677538, 233349006, 245693284, 247414447, 251899199, 251916723, 251917962
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| ChEBI ID |
CHEBI:2914
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| ADReCS Drug ID | BADD_D00187 ; BADD_D00188 | |||
| SuperDrug ATC ID |
M03AC04
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| SuperDrug CAS ID |
cas=064228791
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nicotinic acetylcholine receptor (nAChR) | Target Info | Antagonist | [2], [3], [4] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Highly sodium permeable acetylcholine nicotinic receptors | |||
| Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
| WikiPathways | Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A preliminary assessment of atracurium, a new competitive neuromuscular blocking agent. Acta Anaesthesiol Scand. 1981 Feb;25(1):67-9. | |||
| REF 2 | Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. | |||
| REF 3 | Neuromuscular block. Br J Pharmacol. 2006 Jan;147 Suppl 1:S277-86. | |||
| REF 4 | Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology. 2001 Apr;94(4):643-51. | |||
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