Drug Information

Drug General Information

Top

Drug ID

D0Q2ES

Former ID

DAP000514

Drug Name

Benzonatate

Synonyms

Benzonatato; Benzonatatum; Benzononantin; Benzononatine; Exangit; Tesalon; Tessalin; Tessalon; Ventussin; Tessalon Perles; KM65; Benzonatato [INN-Spanish]; Benzonatatum [INN-Latin]; Tessalon Capsules (TN); Tessalon Perles (TN); Tessalon perles (TN); Tessalon-ciba; Ventussin-loz; Benzonatate (USP/INN); Benzonatate [USAN:INN:BAN];Nonaethyleneglycol monomethyl ether p-n-butylaminobenzoate; P-butylaminobenzoic acid omega-O-methylnonaethyleneglycol ester; Polyethyleneglycol-p-n-butylaminobenzoate methyl ester; P-(n)-Butylaminobenzoesaeure-(nonaaethylenglykol-monomethylaether)-ester; P-(n)-Butylaminobenzoesaeure-(nonaaethylenglykol-monomethylaether)-ester [German]; Benzoic acid, 4-(butylamino)-, 2,5,8,11,14,17,20,23,26-nonaoxaoctacos-28-yl ester; Benzoic acid, 4-(butylamino)-, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester; Benzoic acid, 4-(butylamino)-, 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester (9CI); Benzoic acid, p-(butylamino)-, 2-(2-(2-(2-(2-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl ester; 2,5,8,11,14,17,20,23,26-Nonaoxaoctacosan-28-yl p-(butylamino)benzoate; 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-yl 4-(butylamino)benzoate; 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-(butylamino)benzoate; 2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-butylaminobenzoate; 3,6,9,12,15,18,21,24,27-Nonaoxaoctacos-1-yl 4-(butylamino)benzoate; 3,6,9,12,15,18,21,24,27-nonaoxaoctacosyl 4-butylaminobenzoate; 4-(butylamino)benzoic acid 3,6,9,12,15,18,21,24,27-nonaoxaoctacos-1-yl ester

Click to Show/Hide

Drug Type

Small molecular drug

Indication

Cough [ICD-11: MD12; ICD-10: R05; ICD-9: 786.2]

Approved

[1], [2]

Therapeutic Class

Antitussives

Structure

Download

2D MOL

3D MOL

Formula

C30H53NO11

Canonical SMILES

CCCCNC1=CC=C(C=C1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC

InChI

1S/C30H53NO11/c1-3-4-9-31-29-7-5-28(6-8-29)30(32)42-27-26-41-25-24-40-23-22-39-21-20-38-19-18-37-17-16-36-15-14-35-13-12-34-11-10-33-2/h5-8,31H,3-4,9-27H2,1-2H3

InChIKey

MAFMQEKGGFWBAB-UHFFFAOYSA-N

CAS Number

CAS 104-31-4

PubChem Compound ID

7699

PubChem Substance ID

7783584, 7847308, 8155256, 11112254, 11466040, 11467160, 11485700, 16738876, 29226513, 46506376, 47574768, 47796406, 47945204, 48319874, 48415615, 49699044, 49886266, 50100399, 52308002, 56463355, 57324417, 92125009, 92740984, 103813467, 103914460, 104315714, 117583418, 121362680, 124758300, 124799565, 124882139, 125822995, 126652267, 128566573, 134224183, 134337807, 134972729, 137005903, 138413155, 144076321, 144203949, 152030785, 160964209, 163132883, 164806797, 170465391, 174510230, 175611311, 178127103, 179149334

ChEBI ID

CHEBI:3032

ADReCS Drug ID

BADD_D00240

SuperDrug ATC ID

R05DB01

SuperDrug CAS ID

cas=000104314

Target and Pathway

Top

Target(s)

Voltage-gated sodium channel alpha Nav1.5 (SCN5A)

Target Info

Blocker

[3]

KEGG Pathway

Adrenergic signaling in cardiomyocytes

Pathwhiz Pathway

Muscle/Heart Contraction

Reactome

Interaction between L1 and Ankyrins

WikiPathways

SIDS Susceptibility Pathways

Cardiac Progenitor Differentiation

References

Top

REF 1

URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7611).

REF 2

FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 040587.

REF 3

How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.

Download

Prof. Yuzong CHEN

Prof. Feng ZHU