Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Q5KZ
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Former ID |
DNCL002566
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Drug Name |
SGI110
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Indication | Acute myeloid leukaemia [ICD-11: 2A60] | Phase 3 | [1] | |
Company |
Astex Pharmaceuticals
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Structure |
Download2D MOL
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Formula |
C18H25N9NaO10P
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Canonical SMILES |
[H-].C1C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)O.[Na+]
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InChI |
1S/C18H24N9O10P.Na.H/c19-16-22-6-27(18(31)25-16)12-2-8(9(3-28)35-12)37-38(32,33)34-4-10-7(29)1-11(36-10)26-5-21-13-14(26)23-17(20)24-15(13)30;;/h5-12,28-29H,1-4H2,(H,32,33)(H2,19,25,31)(H3,20,23,24,30);;/q;+1;-1/t7?,8-,9+,10+,11?,12+;;/m0../s1
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InChIKey |
AYXRQJHOBFJIHP-ZWBDGAAVSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Target Info | Modulator | [2] |
KEGG Pathway | Cysteine and methionine metabolism | |||
Metabolic pathways | ||||
MicroRNAs in cancer | ||||
Pathwhiz Pathway | Methionine Metabolism | |||
Pathway Interaction Database | Regulation of retinoblastoma protein | |||
Reactome | PRC2 methylates histones and DNA | |||
NoRC negatively regulates rRNA expression | ||||
DNA methylation | ||||
WikiPathways | Trans-sulfuration and one carbon metabolism | |||
Retinoblastoma (RB) in Cancer | ||||
One Carbon Metabolism | ||||
Trans-sulfuration pathway |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT02348489) SGI-110 in Adults With Untreated Acute Myeloid Leukemia (AML), Not Considered Candidates for Intensive Remission Induction. U.S. National Institutes of Health. | |||
REF 2 | Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts. Epigenetics. 2015;10(3):237-46. |
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