Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QP4N
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| Drug Name |
PMID25666693-Compound-81
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| Drug Type |
Small molecular drug
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| Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
| Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
| Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
| Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
| Company |
Japan Tobacco, Inc
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H14Cl2F6N4O2
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| Canonical SMILES |
C1=CC(=CC=C1C(F)(F)F)NC(=O)C2=CC(=C(C=C2)Cl)N(CC(=O)N)C3=C(C=C(C=N3)C(F)(F)F)Cl
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| InChI |
1S/C22H14Cl2F6N4O2/c23-15-6-1-11(20(36)33-14-4-2-12(3-5-14)21(25,26)27)7-17(15)34(10-18(31)35)19-16(24)8-13(9-32-19)22(28,29)30/h1-9H,10H2,(H2,31,35)(H,33,36)
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| InChIKey |
YLOQUQYZKPTZAV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. | |||
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