Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QY1M
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| Former ID |
DNCL003559
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| Drug Name |
GS-5806
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| Drug Type |
Small molecular drug
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| Indication | Respiratory syncytial virus infection [ICD-11: 1C80; ICD-9: 79.6] | Phase 2 | [1] | |
| Company |
GILEAD
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H30ClN7O3S
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| Canonical SMILES |
CC1=CN2C(=CC(=N2)C3CCCCN3C(=O)C4=C(C=CC(=C4)Cl)NS(=O)(=O)C)N=C1N5CCC(C5)N
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| InChI |
1S/C24H30ClN7O3S/c1-15-13-32-22(27-23(15)30-10-8-17(26)14-30)12-20(28-32)21-5-3-4-9-31(21)24(33)18-11-16(25)6-7-19(18)29-36(2,34)35/h6-7,11-13,17,21,29H,3-5,8-10,14,26H2,1-2H3/t17-,21-/m0/s1
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| InChIKey |
GOFXWTVKPWJNGD-UWJYYQICSA-N
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| CAS Number |
CAS 1353625-73-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Respiratory syncytial virus protein F (RSV F) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02135614) Efficacy, Pharmacokinetics, and Safety of GS-5806 in Hospitalized Adults With Respiratory Syncytial Virus (RSV) Infection. U.S. National Institutes of Health. | |||
| REF 2 | Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-43. | |||
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