Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S6KA
|
|||
| Former ID |
DIB016345
|
|||
| Drug Name |
CALANOLIDE A
|
|||
| Synonyms |
NSC-675451; NSC-664737 (racemate); (+)-(10R,11S,12S)-12-Hydroxy-6,6,10,11-tetramethyl-4-propyl-6,10,11,12-tetrahydro-2H-benzo[1,2-b:3,4-b':5,6-b'']tripyran-2-one; (+)-Calanolide A
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Mycobacterium infection [ICD-11: 1B10-1B21] | Phase 1 | [1] | |
| Company |
Sarawak MediChem Pharmaceuticals
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C22H26O5
|
|||
| Canonical SMILES |
CCCC1=CC(=O)OC2=C1C3=C(C=CC(O3)(C)C)C4=C2C(C(C(O4)C)C)O
|
|||
| InChI |
1S/C22H26O5/c1-6-7-13-10-15(23)26-21-16(13)20-14(8-9-22(4,5)27-20)19-17(21)18(24)11(2)12(3)25-19/h8-12,18,24H,6-7H2,1-5H3/t11-,12-,18+/m1/s1
|
|||
| InChIKey |
NIDRYBLTWYFCFV-FMTVUPSXSA-N
|
|||
| CAS Number |
CAS 142632-32-4
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:65552
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00005120) The Safety and Effectiveness of (+)-Calanolide A in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs. U.S. National Institutes of Health. | |||
| REF 2 | Calanolide A: a natural non-nucleoside reverse transcriptase inhibitor. BETA. 1999 Apr;12(2):8-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.