Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SG0N
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| Former ID |
DIB000694
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| Drug Name |
DB-200
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| Synonyms |
DB-200 series (topical, psoriasis); CPT-1 inhibitor (topical, psoriasis), DARA; DB-200 series (topical, psoriasis), DARA BioSciences
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| Indication | Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Terminated | [1] | |
| Company |
DARA BioSciences
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carnitine O-palmitoyltransferase I (CPT1B) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Fatty acid degradation | |||
| Fatty acid metabolism | ||||
| PPAR signaling pathway | ||||
| AMPK signaling pathway | ||||
| Adipocytokine signaling pathway | ||||
| Glucagon signaling pathway | ||||
| Pathwhiz Pathway | Fatty acid Metabolism | |||
| Reactome | RORA activates gene expression | |||
| PPARA activates gene expression | ||||
| Import of palmitoyl-CoA into the mitochondrial matrix | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Mitochondrial LC-Fatty Acid Beta-Oxidation | ||||
| Nuclear Receptors Meta-Pathway | ||||
| PPAR Alpha Pathway | ||||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Circadian Clock | ||||
| Fatty Acid Beta Oxidation | ||||
| AMPK Signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026687) | |||
| REF 2 | Comparison of the effects of carnitine palmitoyltransferase-1 and -2 inhibitors on rat heart hypertrophy. Cardioscience. 1994 Sep;5(3):193-7. | |||
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