Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SM4F
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| Former ID |
DNC008632
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| Drug Name |
Rac-4'-(1-Imidazol-1-yl-propyl)-biphenyl-4-ol
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| Synonyms |
CHEMBL500680; BDBM50272067; rac-4''-(1-Imidazol-1-yl-propyl)-biphenyl-4-ol; 4''-(1H -Imidazol-1-yl-propyl)-biphenyl-4-ol
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H18N2O
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| Canonical SMILES |
CCC(C1=CC=C(C=C1)C2=CC=C(C=C2)O)N3C=CN=C3
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| InChI |
1S/C18H18N2O/c1-2-18(20-12-11-19-13-20)16-5-3-14(4-6-16)15-7-9-17(21)10-8-15/h3-13,18,21H,2H2,1H3
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| InChIKey |
LYYLXDSSMORBEQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Steroid 17-alpha-monooxygenase (S17AH) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of steroid hormone biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Androgen biosynthesis | ||||
| KEGG Pathway | Steroid hormone biosynthesis | |||
| Metabolic pathways | ||||
| Ovarian steroidogenesis | ||||
| Prolactin signaling pathway | ||||
| Pathwhiz Pathway | Androgen and Estrogen Metabolism | |||
| Steroidogenesis | ||||
| Reactome | Androgen biosynthesis | |||
| Glucocorticoid biosynthesis | ||||
| Endogenous sterols | ||||
| WikiPathways | Metapathway biotransformation | |||
| Steroid Biosynthesis | ||||
| Oxidation by Cytochrome P450 | ||||
| Metabolism of steroid hormones and vitamin D | ||||
| Glucocorticoid & Mineralcorticoid Metabolism | ||||
| Prostate Cancer | ||||
| Phase 1 - Functionalization of compounds | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyl... Eur J Med Chem. 2009 Jul;44(7):2765-75. | |||
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