Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0SZ5A
|
|||
| Drug Name |
Pyrazolopyrimidine derivative 1
|
|||
| Synonyms |
PMID28067079-Compound-78
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Company |
MERZ PHARMA GMBH & CO. KGAA RUSS, Hermann BORTA, Andreas HEERS, Cara HAUPTMEIER, Bernhard BODERKE, Peter PURMANN, Brigitte TARDT, AxeMERZ PHARMA GMBH & CO. KGAA DANYSZ, Wojciech DEKUNDY, Andrzej HECHENBERGER, Mirko HENRICH, Markus JATZKE, Claudia NAGEL, Jens PARSONS, Christopher Graham Raphael WEIL, Tanja MLER, Sibylle FOTINS, Juris GUTCAITS, Aleksandra ZEMRIBO, Ronalds KAUSS, Valerjans KAULINA, Larisa ERDMANE, Elina
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C17H15BrN4O
|
|||
| Canonical SMILES |
CC1C2=CC=CC=C2CCN1C(=O)C3=NN4C=C(C=NC4=C3)Br
|
|||
| InChI |
1S/C17H15BrN4O/c1-11-14-5-3-2-4-12(14)6-7-21(11)17(23)15-8-16-19-9-13(18)10-22(16)20-15/h2-5,8-11H,6-7H2,1H3/t11-/m1/s1
|
|||
| InChIKey |
TUYZYSNXXSTKQX-LLVKDONJSA-N
|
|||
| CAS Number |
CAS 1309783-00-3
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 5 (mGluR5) | Target Info | Modulator | [1] |
| Target's Patent Info | Metabotropic glutamate receptor 5 (mGluR5) | Target's Patent Info | [1] | |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Long-term potentiation | ||||
| Retrograde endocannabinoid signaling | ||||
| Glutamatergic synapse | ||||
| Huntington's disease | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group I pathway | ||||
| Endogenous cannabinoid signaling | ||||
| Reactome | G alpha (q) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | Hypothetical Network for Drug Addiction | |||
| GPCRs, Class C Metabotropic glutamate, pheromone | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.