Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0T0NG
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| Former ID |
DCL000700
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| Drug Name |
Arofylline
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| Synonyms |
Arofyllin; KM09088; Arofylline (USAN/INN); 3-(4-chlorophenyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione; 3-(4-chlorophenyl)-1-propyl-7H-purine-2,6-dione
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| Drug Type |
Small molecular drug
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| Indication | Chronic obstructive pulmonary disease [ICD-11: CA22; ICD-10: J44, J44.9] | Phase 3 | [1] | |
| Company |
Almiral Prodesfarma
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| Structure |
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Download2D MOL |
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| Formula |
C14H13ClN4O2
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| Canonical SMILES |
CCCN1C(=O)C2=C(N=CN2)N(C1=O)C3=CC=C(C=C3)Cl
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| InChI |
1S/C14H13ClN4O2/c1-2-7-18-13(20)11-12(17-8-16-11)19(14(18)21)10-5-3-9(15)4-6-10/h3-6,8H,2,7H2,1H3,(H,16,17)
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| InChIKey |
GVTLDPJNRVMCAL-UHFFFAOYSA-N
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| CAS Number |
CAS 136145-07-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3283044, 6882030, 10256121, 14776327, 14874003, 17397141, 26730391, 46240221, 57350927, 58754695, 77030132, 89758911, 103010060, 103123726, 113458554, 117469418, 124953018, 125144922, 125517596, 128013468, 134339204, 135121134, 137033002, 137242633, 140137137, 160677236, 162309999, 162788494, 179149859, 179417132, 198937617, 224080652, 226491163
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4 (PDE4) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. | |||
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